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Brian Naughton | Sun 25 January 2015 | science | twitter genetics drugs

This twitter conversation is a nice microcosm of what's going on in drug discovery. On the human genetics side, we have Robert Plenge, Daniel MacArthur, Amgen and Regeneron, who believe sequencing humans will be the key to better drugs (a la PCSK9). On the model organism side, we have Ethan Perlstein (and certainly others, perhaps Roger Perlmutter from Merck?), who think that the human sequencing stuff is overblown.

In the end, there's not too much disagreement: humans are good for target discovery, model organisms can be useful models of those targets.

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